Search results for "Steglich esterification"

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2017

The 6-epimer of the plakortide H acid (1), along with the endoperoxides plakortide E (2), plakortin (3), and dihydroplakortin (4) have been isolated from a sample of the Caribbean sponge Plakortis halichondrioides. To perform a comparative study on the cytotoxicity towards the drug-sensitive leukemia CCRF-CEM cell line and its multi-drug resistant subline CEM/ADR5000, the acid of plakortin, namely plakortic acid (5), as well as the esters plakortide E methyl ester (6) and 6-epi-plakortide H (7) were synthesized by hydrolysis and Steglich esterification, respectively. The data obtained showed that the acids (1, 2, 5) exhibited potent cytotoxicity towards both cell lines, whereas the esters s…

biology010405 organic chemistryStereochemistryPharmaceutical Sciencemedicine.diseasebiology.organism_classification01 natural sciences0104 chemical sciencesMultiple drug resistance03 medical and health sciencesLeukemiaHydrolysisSponge0302 clinical medicineCell culture030220 oncology & carcinogenesisDrug DiscoverymedicineSteglich esterificationCytotoxicityPharmacology Toxicology and Pharmaceutics (miscellaneous)IC50Marine Drugs

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